Hybrid Evidence-Informed Synthesis of Resting-State Functional Connectivity Alterations in Mild Traumatic Brain Injury

This evidence synthesis integrates umbrella review principles to identify convergent patterns of brain network dysfunction in mild traumatic brain injury (mTBI) using resting-state functional MRI, while critically examining methodological constraints and neurovascular confounds. The authors conclude that mTBI shows distributed connectivity disturbances at the network level, but emphasize findings represent qualitative convergence rather than quantitative generalization, highlighting the need for future standardized, multimodal, and longitudinal imaging studies.