Clinical Presentations and Psychosocial Care in Adults with Down Syndrome and Dementia: Case Studies

Adults with Down syndrome carry a >95% lifetime risk of developing dementia, particularly Alzheimer's disease, with median onset around 55 years due to trisomy 21. This clinical case study examines two complex cases of adults with DS and comorbid Alzheimer's disease, highlighting medical presentations, diagnostic pathways, and psychosocial care considerations.