Alzheimer's disease histopathology in the human Down syndrome retina and in hiPSC-derived retinal organoids

This study investigates Alzheimer's disease pathological features in retinal tissue from Down syndrome individuals and in laboratory-generated retinal tissue models derived from induced pluripotent stem cells. The research uses histopathological analysis to understand how neurodegeneration associated with Down syndrome manifests in the retina, potentially offering insights into disease mechanisms.