Sex, menopause, and hormone therapy moderate PET tau and amyloid-beta association in cognitively unimpaired adults with Down syndrome

This study examines how biological sex, menopausal status, and hormone therapy influence the relationship between Alzheimer's disease biomarkers (tau and amyloid-beta) detected via PET imaging in cognitively intact adults with Down syndrome. The research suggests sex-specific and hormonal factors may modulate neuropathological changes in this population at high risk for early-onset dementia.