Validation of 2015 MDS Parkinson Disease Diagnostic Criteria in Autopsy-Confirmed Cases: A Scoping Review

This systematic literature review (1988–2024) evaluated the validity of the 2015 International Parkinson and Movement Disorder Society diagnostic criteria using pathologically-confirmed PD cases, identifying which supportive criteria and red flags best distinguish PD from atypical parkinsonian disorders. The study found that excellent levodopa response and rest tremor were most useful for PD diagnosis, though some red flags (supranuclear gaze palsy, rapid gait progression, bilateral symptoms) occurred in >5% of confirmed PD cases, suggesting potential criteria refinement.