Pathogenic GRN Variants Found in 0.1% of Parkinson's Disease Patients: Implications for Differential Diagnosis

A study of over 18,500 PD patients identified pathogenic or likely pathogenic GRN variants in 24 patients (0.13%), suggesting that GRN-associated frontotemporal dementia can clinically mimic Parkinson's disease. The findings recommend comprehensive genetic testing including GRN analysis for patients with parkinsonism to improve diagnostic accuracy and inform treatment decisions.