Efficacy of Vitamin D3 Supplementation in Raising 25(OH)D Levels in Chronic Spinal Cord Injury: A Randomized Controlled Trial

A 12-month randomized double-blind placebo-controlled trial examined vitamin D3 supplementation efficacy in 42 individuals with chronic spinal cord injury and baseline vitamin D insufficiency. High-dose supplementation (24,000 IU every 2 weeks) achieved sufficient 25(OH)D levels in 46% of participants, with dose-response effects observed and good tolerability; outcomes were influenced by lesion completeness, baseline levels, BMI, and season.