Baseline Depressive Symptom Profiles Associated with Remission in Major Depression: PANDORA Trial Analysis

This secondary analysis of 215 adults with major depression found that 53% achieved remission at 12 weeks on antidepressants, with higher baseline severity and specific symptoms (suicidal ideation, psychomotor retardation, hypochondriasis) predicting lower remission odds. Sex differences emerged, with psychomotor retardation and suicidal ideation predicting non-remission in women, while hypochondriasis was the key marker in men.