Down syndrome and Alzheimer's disease: Oxidative stress in the neurodegenerative process

This study compared antioxidant enzyme activity and oxidative stress markers in blood samples from 120 individuals with and without Down syndrome, examining associations with cognitive decline. Results showed elevated superoxide dismutase and catalase activity in the Down syndrome group regardless of cognitive status, suggesting altered antioxidant response related to chromosome 21 trisomy may contribute to neurodegenerative pathology.