APOE ε4 Does Not Increase Rate of Amyloid Accumulation or Tau Phosphorylation in Adults with Down Syndrome

This research examines whether the APOE ε4 genetic variant, a known Alzheimer's risk factor in the general population, accelerates pathological protein accumulation (amyloid and tau) in adults with Down syndrome. The study finds no significant association between APOE ε4 status and the rate of these biomarker changes in this population.