The Diagnostic Performance of Nuchal Translucency Alone as a Screening Test for Down Syndrome: A Systematic Review and Meta-analysis

This systematic review and meta-analysis evaluates the diagnostic accuracy of nuchal translucency (NT) measurement via first-trimester ultrasound as a sole screening test for Down syndrome (trisomy 21). The study addresses the clinical need in resource-limited settings where NT ultrasound is the only available prenatal screening method, examining its performance compared to combined screening approaches and other biomarker tests.