Comparison of pTau217 and Tau PET imaging between Down syndrome and neurotypical adults at risk for Alzheimer's disease

This study compares phosphorylated tau-217 (pTau217) levels and tau positron emission tomography (PET) imaging findings between adults with Down syndrome and neurotypical adults who are at risk for Alzheimer's disease. The research aims to characterize tau pathology biomarkers as potential early indicators of neurodegeneration in these populations.