Genetic Risk Mapping of Psychiatric Disorders: A Swedish Population Register Study

This study used Swedish national health registers to map genetic relationships among 12 psychiatric and substance use disorders, organizing them by genetic risk for major depression and drug use disorder. The analysis revealed two distinct clusters—internalizing disorders (depression, anxiety) with moderate depression risk and low drug risk, and externalizing disorders (ADHD-spectrum, substance use) with elevated risk across both dimensions, with significant sex, age, and recurrence patterns.