Daridorexant for Adults with ADHD and Insomnia Disorder: An Exploratory Study

This naturalistic one-month study examined daridorexant 50 mg nightly in 24 adults with comorbid ADHD and insomnia, finding significant improvements in sleep quality (ISI/SCI scores), sleep efficiency via actigraphy, and sustained attention on cognitive testing. Secondary improvements were noted in ADHD symptoms and mood, with 62.5% achieving clinically meaningful insomnia improvement.