Cognition in Multiple Sclerosis in the Modern Diagnostic and Treatment Era

This study re-evaluates the classical model that processing speed is the primary cognitive deficit in MS by examining patients diagnosed and treated in the modern era (2001-2025). Early relapsing-remitting MS patients showed memory deficits but normal cognitive speed, contradicting the traditional speed-centric model and suggesting disease-modifying therapies may have altered the cognitive profile of MS.