Impaired Cerebrovascular Reactivity Associated with Disability and Cognitive Performance in Relapsing-Remitting Multiple Sclerosis

This cross-sectional study found that patients with relapsing-remitting MS have reduced cerebrovascular reactivity (measured by Breath-Holding Index) compared to healthy controls, independent of demographic factors. Lower cerebrovascular reactivity was independently associated with greater neurological disability and slower processing speed on cognitive testing.