Treatment of Multiple Sclerosis: Evidence-Based Approaches to Relapses and Disease-Modifying Therapy Selection

The article reviews evidence-based management of MS relapses using high-dose corticosteroids while distinguishing true MS-related symptoms from transient worsening caused by systemic factors. It emphasizes shared decision-making for selecting higher-efficacy therapies or escalation strategies, with appropriate screening and ongoing safety monitoring, noting that benefits vary between relapsing and progressive MS presentations.