Amyloid Status as a Moderator of Physical Activity's Effect on Parkinson's Disease Progression

This longitudinal study examined whether amyloid copathology modifies how physical activity influences Parkinson's disease progression in 245 patients followed over 4+ years. Results showed amyloid positivity significantly moderated physical activity's effects on motor severity, with amyloid-negative patients showing slower biomarker increases (neurofilament light chain and tau) associated with higher physical activity levels.