Aberrant Potassium Handling by Astrocytes and Epileptic Seizures: A Synthetic Update

This review examines how impaired potassium clearance by astrocytes contributes to temporal lobe epilepsy, focusing on dysfunctional ion channels and transporters including Kir4.1, aquaporin 4, and Na⁺/K⁺-ATPase. The analysis integrates molecular mechanisms underlying seizure induction and propagation related to extracellular potassium accumulation in epileptic brain tissue.