Combined TRPM4/NMDA Receptor and Extrasynaptic NMDA Inhibition as Therapeutic Target for Seizure Suppression and Cognitive Improvement in Epilepsy

This preclinical study investigates the effects of various NMDA receptor modulators and channel inhibitors on seizure frequency and cognitive function in a genetic rat epilepsy model with comorbid cognitive impairment. Combination treatments, particularly memantine with FP802, showed promise in reducing seizures while improving mood-related behaviors and restoring abnormal glutamate/glutamatergic signaling patterns.