Causal relationship between inflammatory proteins and ADHD: A Mendelian randomization analysis with serum metabolite mediation

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This Mendelian randomization study analyzed GWAS data from over 38,000 ADHD cases to investigate whether 91 inflammatory proteins causally influence ADHD risk, finding only CD40 receptor levels showed a significant protective association. A mediation analysis explored whether identified inflammatory proteins affect ADHD through specific serum metabolites, though effects were modest and did not reach statistical significance.

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MED — Fri May 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time) · Read full article (translated)
MED — Mon Jun 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time) · Read full article (translated)

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