Death-Associated Protein Kinase 1 and Its Role in Alzheimer's Disease Pathogenesis: A Molecular Review

This review examines death-associated protein kinase 1 (DAPK1) as a promising therapeutic target for Alzheimer's disease, exploring its involvement in key pathogenic mechanisms including amyloid-beta accumulation, tau phosphorylation, neuronal cell death, and mitochondrial dysfunction. The authors discuss potential treatment strategies using small molecules, microRNAs, and natural compounds that could modulate DAPK1 activity.