Hippocampal GFAP in aging: Associations with Alzheimer's disease and LATE-NC pathologies and cognitive decline in older adults

This neuropathological study found that glial fibrillary acidic protein (GFAP) burden in the hippocampus is associated with both Alzheimer's disease-related pathologies (particularly neurofibrillary tangles and LATE-NC) and cognitive decline in older adults. Hippocampal GFAP appears to contribute to cognitive decline independently of these pathologies, suggesting it may be an important marker of neurodegeneration.