Evolution of Addiction Neurobiology in Kandel's Principles of Neural Science Across Six Editions (1981-2021)

This review traces how the understanding of addiction's neurobiological mechanisms has evolved across six editions of a major neuroscience textbook, from initial psychological theories to modern knowledge about dopamine, basal ganglia, and learning systems. The analysis demonstrates a conceptual shift from homeostatic models toward understanding addiction as a disorder of motivation, learning, and habit formation.