Glucocorticoid receptor blockade reverses heroin and alcohol withdrawal-induced hyperalgesia in rats

This preclinical study demonstrates that mifepristone, a glucocorticoid receptor antagonist, can reverse pain hypersensitivity (hyperalgesia) occurring during alcohol and opioid withdrawal in rats, with differential effects depending on substance and sex. The findings suggest targeting glucocorticoid signaling may address withdrawal-related pain, a significant barrier to addiction recovery.