Efficacy and Safety of Psychoactive Tryptamines in Addiction: A Systematic Review

This systematic review examined four clinical trials (176 patients with alcohol use disorder) investigating psychoactive tryptamines like dipropyltryptamine and diethyltryptamine as addiction treatments. Results showed abstinence rates ranging from 10-38% at follow-up, with no significant differences compared to control groups and poorly reported adverse effects, indicating limited evidence for efficacy of these compounds in addiction treatment.