Efficacy and Safety of Centanafadine in ADHD: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

This systematic review and meta-analysis synthesizes evidence from randomized controlled trials examining centanafadine, a triple monoamine reuptake inhibitor, as a non-stimulant treatment for ADHD compared to placebo. The study evaluated efficacy using validated ADHD symptom rating scales and clinical global impression measures, alongside safety outcomes including adverse event incidence.