Serum Creatinine Levels in Children With Down Syndrome: A Single-Centre Retrospective Study in Ireland

This retrospective study of 194 children with Down syndrome found that 26.8% had elevated serum creatinine levels compared to the expected 2.5% in standard pediatric populations, with 21.6% showing persistently elevated values. While approximately one-third of children with available height data showed reduced estimated glomerular filtration rates, the authors note further research is needed to determine the clinical significance of these findings.