Obesity and Cardiovascular Risk in Down Syndrome: Challenges and Updated Management

This systematic review examines how obesity contributes to cardiovascular risk in individuals with Down syndrome, finding that DS patients commonly experience central adiposity, metabolic abnormalities, and sedentary behavior that may amplify cardiovascular strain. Early, targeted interventions focusing on nutrition, physical activity, and caregiver support are recommended to reduce long-term cardiometabolic burden in this population.