Clinical and Cognitive Mediators of Depression in ADHD: A Developmental Study

This longitudinal study examined how clinical factors (irritability, anxiety), cognitive processes (emotion recognition, working memory), and negative thought patterns mediate the relationship between ADHD and subsequent depression across childhood, adolescence, and adulthood using two large cohorts. Clinical mediators were most influential in childhood and young adulthood, while negative thought patterns played a larger role in adolescence, with combined mediators explaining 29-48% of the ADHD-depression effect.