Synergistic-Redundant Dysfunction in Autism Spectrum Disorder: Heterogeneity and Molecular Mechanisms

This study analyzed functional brain connectivity in 842 individuals with ASD and 933 controls across age groups to examine synergistic and redundant neural interactions. Findings show age-dependent changes in brain network patterns and associations with specific neurotransmitter systems (dopamine, GABA, opioid) and genes related to synaptic function and neuronal development.