Maternal anti-CRMP1 antibodies induce autism-like behaviors in offspring mice through disrupted axon development

This study demonstrates that maternal autoantibodies against CRMP1 (a neural protein) cross the placenta and persist in offspring, causing autism-like behavioral changes including increased repetitive behaviors and sensory changes. Molecular analysis reveals these antibodies disrupt genes critical for presynaptic development and axon guidance, providing evidence for how maternal autoimmunity may contribute to ASD pathogenesis.