Sex differences in autism spectrum disorder: behavioral and sensory phenotypes in humans and mouse models

This multimodal study examined sex-dependent autism phenotypes in adults with ASD and a mouse genetic model, finding that females reported greater sensory sensitivity and showed lower clinician-rated behavioral impairments despite similar self-reported autistic traits compared to males. Female mice with the 15q duplication also displayed heightened sensory reactivity, suggesting sex-specific neurobiological mechanisms in autism.