From Allostatic Load to Burnout: HPA Axis Dysregulation and the Invisibility of Aging in the Autism Spectrum – An Integrative Review

This integrative review synthesizes evidence on HPA axis dysregulation in autistic adults and older adults, examining stress responses via salivary cortisol across seven empirical studies (n=166). Findings reveal chronic HPA axis dysregulation with anticipatory stress in social situations and sleep impairments, while technology-mediated interventions show promise in reducing stress reactivity.